​Pharmacology - Aspirin

​Pharmacology - Aspirin  
Aspirin has antiplatelet properties, in addition to analgesic and anti-inflammatory properties.

Mode of Action 
COX-1 is rendered inactive in an irreversible manner; the equilibrium between TXA2 and PGI2 in the platelet/vascular endothelium axis is disrupted.

Orally administered in low doses only. When urine is alkalinized, there is an increase in an individual's urine excretion. In the case of interactions, the effects of aspirin may be amplified with anticoagulants and thrombolytic .


Use in Clinical Settings
In order to lessen the likelihood of myocardial infarction or transient ischemic events, it is recommended that occasional modest dosages be administered orally. These doses should decrease platelet TXA2 without significantly lowering endothelial PGI2. When treating acute strokes, it is also employed.

Adverse Effects
Bleeding in the gastrointestinal tract as a result of a reduction in the cytoprotective activity of PGs, which includes decreased acid production, increased mucus, and bicarbonate; bronchospasm in certain individuals. First, respiratory alkalosis is brought on by toxic doses, and then acidosis follows.