​Pharmacology - Sildenafil

​Pharmacology - Sildenafil 
Expression of Sildenafil 
Facilitates relaxation of the smooth muscle of the copora cavernosa that is non-vascular. After that, blood flows into the cavenosa sinuses at a pressure that is nearly equivalent to that of the arterial blood, which causes the penis to enlarge and become erected.

Method of Operation 
Phosphodiesterase type V, an enzyme that ordinarily does the conversion of cGMP to 5'-GMP, is inhibited by this substance.
A higher concentration of cGMP is produced as a result of this, which suppresses the contractile processes of the muscle, so allowing for relaxation.When taken orally, the peak effect comes between thirty and one hundred and twenty minutes later.

To treat erectile dysfunction in clinical settings.

Allergies and Reactions 
A decrease in blood pressure, headache, and flushing are some of the side effects that might occur as a result of the drug's activity on other peripheral vascular beds.