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Symptoms and Signs – Differential Diagnosis of Howell-Jolly bodies
Hypergammaglobulinaemia
Hyposplenism: sickle cell disease, coeliac disease/dermatitis herpetiformis,
Iron deficiency
Leukaemia
Megaloblastic anaemia
Post-splenectomy
ulcerative colitis, tropical sprue, amyloidosis, essential thrombocythaemia
Hypergammaglobulinaemia
Hyposplenism: sickle cell disease, coeliac disease/dermatitis herpetiformis,
Iron deficiency
Leukaemia
Megaloblastic anaemia
Post-splenectomy
ulcerative colitis, tropical sprue, amyloidosis, essential thrombocythaemia
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Symptoms and Signs – Differential Diagnosis of Raised Homocysteine
Disease: hypothyroidism, renal failure, breast/ovarian cancer
Drugs: methotrexate, theophylline, phenytoin
Genetic: Cystathionine beta 1-synthetase deficiency, MTHFR polymorphism
Lifestyle: aging, smoking, increase coffee consumption
Vitamin deficiency: B6 , B12, folate
Disease: hypothyroidism, renal failure, breast/ovarian cancer
Drugs: methotrexate, theophylline, phenytoin
Genetic: Cystathionine beta 1-synthetase deficiency, MTHFR polymorphism
Lifestyle: aging, smoking, increase coffee consumption
Vitamin deficiency: B6 , B12, folate
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Symptoms and Signs – Differential Diagnosis of Hepatosplenomegaly
Worldwide: malaria, schistosomiasis, leishmaniasis
Portal hypertension (See Portal hypertension)
Other: amyloidosis, storage disorders, e.g. Gaucher's disease, infantile polycystic disease
Myeloproliferative disorders*
Megaloblastic anaemia (e.g. pernicious anaemia)
Lymphoproliferative disorders**
Infection: hepatitis B or C, EBV, CMV, leptospirosis, toxoplasmosis, tuberculosis, brucellosis
Worldwide: malaria, schistosomiasis, leishmaniasis
Portal hypertension (See Portal hypertension)
Other: amyloidosis, storage disorders, e.g. Gaucher's disease, infantile polycystic disease
Myeloproliferative disorders*
Megaloblastic anaemia (e.g. pernicious anaemia)
Lymphoproliferative disorders**
Infection: hepatitis B or C, EBV, CMV, leptospirosis, toxoplasmosis, tuberculosis, brucellosis
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Symptoms and Signs – Differential Diagnosis of Soft Second Heart Sound
Aortic stenosis
Pulmonary stenosis
Aortic stenosis
Pulmonary stenosis
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Symptoms and Signs – Differential Diagnosis of Splitting of S2
Wide
Delayed activation of right ventricle
RBBB, left ventricular pacing, left ventricular preexcitation (WolffParkinson-
White syndrome)
Prolonged right ventricular ejection time
Pulmonary stenosis, pulmonary hypertension
Reduced Left ventricular ejection time
Mitral regurgitation, VSD
Wide fixed splitting
ASD
Reversed splitting
Delayed activation of left ventricle
LBBB, right ventricular pacing, right ventricular preexcitation
Prolonged left ventricular ejection time
Aortic stenosis, HOCM, hypertension, PDA
Wide
Delayed activation of right ventricle
RBBB, left ventricular pacing, left ventricular preexcitation (WolffParkinson-
White syndrome)
Prolonged right ventricular ejection time
Pulmonary stenosis, pulmonary hypertension
Reduced Left ventricular ejection time
Mitral regurgitation, VSD
Wide fixed splitting
ASD
Reversed splitting
Delayed activation of left ventricle
LBBB, right ventricular pacing, right ventricular preexcitation
Prolonged left ventricular ejection time
Aortic stenosis, HOCM, hypertension, PDA
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Symptoms and Signs – Differential Diagnosis of Fourth Heart Sound
Pulmonary stenosis
Myocardial infarction
Hypertrophic cardiomyopathy
Hypertensive heart disease
Aortic stenosis
Pulmonary stenosis
Myocardial infarction
Hypertrophic cardiomyopathy
Hypertensive heart disease
Aortic stenosis
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Symptoms and Signs – Differential Diagnosis of Third Heart Sound
Ventricular failure
Normal in those
Ventricular failure
Normal in those
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Symptoms and Signs – Differential Diagnosis of Variable intensity of First Heart Sound
Nodal or ventricular tachycardia
AV block
Atrial fibrillation
Nodal or ventricular tachycardia
AV block
Atrial fibrillation
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Symptoms and Signs – Differential Diagnosis of Loud Second Heart Sound
loud
Systemic hypertension, tachycardia
Pulmonary hypertension
loud
Systemic hypertension, tachycardia
Pulmonary hypertension
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Symptoms and Signs – Differential Diagnosis of Hemianopia
Bitemporal
Superior temporal quadrants involved first
Pituitary adenoma, meningioma, carotid aneurysm
Nasopharyngeal carcinoma
Sphenoid sinus mucocele
Inferior temporal quadrants involved first
Craniopharyngioma
Third ventricular tumour
Homonymous
Involvement of:
Optic tract or
Optic radiation (in parietal or temporal lobes) or
Occipital cortex by: CVA (sudden): stroke/transient ischaemic attack (TIA)
Masses: gliomas, metastasis, abscess