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​Symptoms and Signs – Differential Diagnosis of Mesenteric Venous Thrombosis
• Trauma (operative venous injury, abdominal trauma, post splenectomy)
• Other: CHF, renal failure, portal hypertension, decompression sickness
• Inflammatory conditions (pancreatitis, diverticulitis, appendicitis, cholangitis)
• Hypercoagulable states (protein C or S deficiency, antithrombin III deficiency, factor V Leyden, malignant neoplasm, polycythemia vera, sickle cell disease, homocystinemia, lupus anticoagulant, cardiolipin antibody)
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​Symptoms and Signs – Differential Diagnosis of Metabolic Syndrome
• Other forms of diabetes (type 1)
• Other causes of weight gain or obesity (Cushing’s syndrome, hypothyroidism)
• Other causes of hypertension (Cushing’s syndrome, hyperaldosteronism)
• Other causes of hyperlipidemia (familial hyperlipidemia, hypothyroidism)
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​Symptoms and Signs – Differential Diagnosis of Metastatic Neoplasms
TO BONE
• Thyroid
• Prostate
• Lung
• Kidney
• Endometrium
• Cervix
• Breast
• Bladder
• Melanoma
TO BRAIN
• Thyroid
• Skin
• Sinuses
• Sarcoma
• Melanoma
• Lung
• GU tract
• Colon
• Breast
TO LIVER
• Stomach
• Sarcoma
• Pancreas
• Lymphomas
• Lung
• Colon
• Choriocarcinoma
• Bronchus
• Breast
TO LUNG
• Thyroid
• Testis
• Stomach
• Melanoma
• Kidney
• Colon
• Breast
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​Symptoms and Signs – Differential Diagnosis of Metatarsalgia
• Splayfoot
• Osteoarthritis, rheumatoid arthritis
• MTP synovitis
• Morton’s neuroma
• Hallux rigidus
• Freiberg’s disease (avascular necrosis of second metatarsal head)
• Cavus foot (high arch)
• Bunion deformity
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​Symptoms and Signs – Differential Diagnosis of Melanoma
• Basal cell carcinoma
• Blue nevus
• Cherry hemangioma
• Dermatofibroma
• Dysplastic nevi
• Keratoacanthoma
• Lentigo
• Pyogenic granuloma
• Seborrheic keratosis
• Squamous cell carcinoma
• Subungual hematoma
• Vascular lesions
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​Symptoms and Signs – Differential Diagnosis of Melanonychia
• Addison’s disease
• Basal cell carcinoma
• Bowen’s disease
• HIV infection
• Lichen planus
• Medications (e.g., AZT, 5-fluorouracil, doxorubicin, psoralens)
• Melanocyte hyperplasia
• Nail matrix melanoma
• Nail matrix nevus
• Onychomycosis
• Pregnancy
• Pustular psoriasis
• Subungual keratosis
• Trauma
• Verrucae
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​Symptoms and Signs – Differential Diagnosis of Memory Loss Symptoms, Elderly Patients
• Age-related mild cognitive impairment
• Alzheimer’s disease
• B12 deficiency
• Cerebrovascular infarcts
• Chronic hypoxia
• Chronic renal failure
• Depression (pseudodementia)
• Frontotemporal dementia
• Hepatic disease
• Hyperthyroidism
• Hypothyroidism
• Lewy body dementia
• Medications (e.g., anticholinergics, sedatives)
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​Symptoms and Signs – Differential Diagnosis of Meningioma
• Metastatic disease from lymphoma or adenocarcinoma, inflammatory disease, or infections such as tuberculosis
• Ependymoma, lipoma, and metastases within the spinal cord
• Acoustic schwannoma (typically at the pontocerebellar junction)
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