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Symptoms and Signs – Differential Diagnosis of Gingival hypertrophy
Familial
Drugs: ciclosporin, phenytoin, Ca channel antagonists (nifedipine, diltiazem), OCP
Acute leukaemia
Tuberous sclerosis
Pregnancy
Glossitis
Familial
Drugs: ciclosporin, phenytoin, Ca channel antagonists (nifedipine, diltiazem), OCP
Acute leukaemia
Tuberous sclerosis
Pregnancy
Glossitis
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Symptoms and Signs – Differential Diagnosis of Iron deficiency
Deficiency of folate, B12, niacin (B3), thiamine (B 1), riboflavin, Zn
Candidiasis
Syphilis (rare)
Deficiency of folate, B12, niacin (B3), thiamine (B 1), riboflavin, Zn
Candidiasis
Syphilis (rare)
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Symptoms and Signs – Differential Diagnosis of Glycosuria
Diabetes (1° and 2°)
Pregnancy
Chronic renal failure
Renal tubular dysfunction/damage (e.g. multiple myeloma, heavy metals,
Wilson's disease)
Diabetes (1° and 2°)
Pregnancy
Chronic renal failure
Renal tubular dysfunction/damage (e.g. multiple myeloma, heavy metals,
Wilson's disease)
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Symptoms and Signs – Differential Diagnosis of Goitre
Simple goitre {euthyroid): puberty, pregnancy
Hyperthyroidism: Graves' disease, toxic adenoma, toxic multinodular goitre with
one palpable nodule, thyroiditis
Hypothyroidism: Hashimoto's disease
Lithium, antithyroid drugs, iodine deficiency/excess, dyshormogenesis
Thyroid cyst
Thyroid carcinoma: papillary, follicular, anaplastic, medullary, lymphoma
Simple goitre {euthyroid): puberty, pregnancy
Hyperthyroidism: Graves' disease, toxic adenoma, toxic multinodular goitre with
one palpable nodule, thyroiditis
Hypothyroidism: Hashimoto's disease
Lithium, antithyroid drugs, iodine deficiency/excess, dyshormogenesis
Thyroid cyst
Thyroid carcinoma: papillary, follicular, anaplastic, medullary, lymphoma
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Symptoms and Signs – Differential Diagnosis of Gynaecomastia
Chronic liver disease
Chronic renal failure
Drugs: spirinolactone, cimetidine, cyproterone acetate, chlorpromazine,
Hyperthyroidism
Hypogonadism
oestrogens, digoxin, drugs of abuse (heroin, marijuana)
Physiological: puberty, elderly
Pseudogynaecomastia: e.g. in obese men
testicular)
Tumours: ectopic hCG (e.g. hepatoma and lung), oestrogen-producing (e.g.
Unilateral
Breast carcinoma
Lipoma, lymphangioma, neurofibroma, haematoma, dermoid cyst
Chronic liver disease
Chronic renal failure
Drugs: spirinolactone, cimetidine, cyproterone acetate, chlorpromazine,
Hyperthyroidism
Hypogonadism
oestrogens, digoxin, drugs of abuse (heroin, marijuana)
Physiological: puberty, elderly
Pseudogynaecomastia: e.g. in obese men
testicular)
Tumours: ectopic hCG (e.g. hepatoma and lung), oestrogen-producing (e.g.
Unilateral
Breast carcinoma
Lipoma, lymphangioma, neurofibroma, haematoma, dermoid cyst
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Symptoms and Signs – Differential Diagnosis of Haemarthrosis
Haematological: Clotting disorders, sickle cell disease, drugs
Infection: Septic arthritis, TB
Joint diseases: Osteoarthritis, gout, pseudogout
Neurological: Charcot's joint
Scurvy
Trauma: iatrogenic, post-operative, fracture, meniscus tear, ligamentous injury (e.g. anterior cruciate)
Tumour: pigmented villonodular synovitis
Vascular: haemangioma, arteriovenous malformation, aneurysm
Haematological: Clotting disorders, sickle cell disease, drugs
Infection: Septic arthritis, TB
Joint diseases: Osteoarthritis, gout, pseudogout
Neurological: Charcot's joint
Scurvy
Trauma: iatrogenic, post-operative, fracture, meniscus tear, ligamentous injury (e.g. anterior cruciate)
Tumour: pigmented villonodular synovitis
Vascular: haemangioma, arteriovenous malformation, aneurysm
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Symptoms and Signs – Differential Diagnosis of Haematuria
disease, leukaemia), anticoagulants
Drugs (senna, rifamipcin)
e.g. cyclophosphamide, excessive exercise
Food: beetroot
General: haematological disorders (haemophilia, thrombocytopenia, sickle cell
Haemoglobinuria/myoglobinuria
Infection: UTI, rarely TB, schistosomiasis
Kidney, bladder, ureter or urethra
Other causes of urine discoloration
Other causes: glomerulonephritis, lgA nephropathy, interstitial nephritis, cystic renal disease, emboli, renal vein thrombosis, vascular malformation, drugs,
Porphyria (acute intermittent)
Prostate: benign prostatic hyperplasia, prostate cancer, prostatitis
Stones
Trauma
Tumours
disease, leukaemia), anticoagulants
Drugs (senna, rifamipcin)
e.g. cyclophosphamide, excessive exercise
Food: beetroot
General: haematological disorders (haemophilia, thrombocytopenia, sickle cell
Haemoglobinuria/myoglobinuria
Infection: UTI, rarely TB, schistosomiasis
Kidney, bladder, ureter or urethra
Other causes of urine discoloration
Other causes: glomerulonephritis, lgA nephropathy, interstitial nephritis, cystic renal disease, emboli, renal vein thrombosis, vascular malformation, drugs,
Porphyria (acute intermittent)
Prostate: benign prostatic hyperplasia, prostate cancer, prostatitis
Stones
Trauma
Tumours
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Symptoms and Signs – Differential Diagnosis of Haemoptysis
General bleeding diathesis
Heart: mitral stenosis
Lung: infection {TB, pneumonia, abscess, bronchitis, bronchiectasis fungi, parasites), pulmonary embolism, malignancy, vasculitis (e.g. Wegener's granulomatosis, Goodpasture's disease), trauma, foreign body
Rarer causes: arteriovenous malformation, amyloidosis, sarcoidosis
General bleeding diathesis
Heart: mitral stenosis
Lung: infection {TB, pneumonia, abscess, bronchitis, bronchiectasis fungi, parasites), pulmonary embolism, malignancy, vasculitis (e.g. Wegener's granulomatosis, Goodpasture's disease), trauma, foreign body
Rarer causes: arteriovenous malformation, amyloidosis, sarcoidosis
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Symptoms and Signs – Differential Diagnosis of Halitosis
GI: achalasia, oesophageal stricture, GORD
Lung: infections, bronchiectasis
Mouth: Poor dental hygiene, dental plaque, gingivitis, oropharyngeal malignancy
Nasopharynx: Atrophic rhinitis, chronic sinusitis and post-nasal drip, chronic tonsillitis, pharyngeal pouch
GI: achalasia, oesophageal stricture, GORD
Lung: infections, bronchiectasis
Mouth: Poor dental hygiene, dental plaque, gingivitis, oropharyngeal malignancy
Nasopharynx: Atrophic rhinitis, chronic sinusitis and post-nasal drip, chronic tonsillitis, pharyngeal pouch
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Symptoms and Signs – Differential Diagnosis of Hallucination
Alcoholic hallucinosis
Cerebrovascular (stroke), infection, toxidmetabolic (e.g. alcohol, hallucinogens, e.g. LSD), drug-induced psychosis (e.g. amphetamine, cocaine)
Delirium
Dementia
Mania with psychosis
Psychiatric
Puerperal psychosis
Schizophrenia/schizoaffective disorder
Seizures
Sensory organ disease, e.g. retinal ischaemia/optic nerve lesions
Severe depression with psychosis
Alcoholic hallucinosis
Cerebrovascular (stroke), infection, toxidmetabolic (e.g. alcohol, hallucinogens, e.g. LSD), drug-induced psychosis (e.g. amphetamine, cocaine)
Delirium
Dementia
Mania with psychosis
Psychiatric
Puerperal psychosis
Schizophrenia/schizoaffective disorder
Seizures
Sensory organ disease, e.g. retinal ischaemia/optic nerve lesions
Severe depression with psychosis