​Dermatology - Cutaneous B Cell Lymphoma

​Dermatology - Cutaneous B Cell Lymphoma 
Cutaneous B Cell Lymphoma refers to a type of lymphoma that mostly affects the skin. 

The clonal expansion of B lymphocytes is infrequent, accounting for just 20% of all cutaneous lymphomas. This expansion can be limited to the skin or linked to systemic B cell lymphoma. The typical age of onset is usually in the sixth decade of life.

Abnormalities
The crops consist of nodules and plaques that are firm, smooth, and painless. They are red to plum in color and can be found on the skin or beneath it.
The diagnosis is established using gene-typing investigations that demonstrate rearrangement of immunoglobulin genes.
It is important to do a comprehensive investigation of patients to determine if they have nodal and extracutaneous disease. If such disease is present, bone marrow, lymph node, and peripheral blood investigations will reveal comparable morphologic, cytochemical, and immunologic characteristics as the cutaneous infiltrates.
The treatment involves administering x-ray therapy to specific lesions and chemotherapy for disease that has spread across the body.