​Dermatology - Melanoma In Situ (MIS)

​Dermatology - Melanoma In Situ  (MIS)
When melanoma cells are restricted to the epidermis, above the basement membrane, MIS is largely employed as a histological definition.
Hyperplasia, atypia, and spread of basilar melanocytic atypia can occur in single file alignment along the basal membrane (lentigo maligna, LM) or dispersed in a pagetoid pattern throughout the epidermis (superficial spreading melanoma, SSM).
The LM or flat SSM clinical correlations of MIS are known. Because LM is flat and lies at the skin's surface, it is either a macule with scarcely noticeable elevation, uneven boundaries, and noticeable color variation, with brown, black, or reddish tones predominating but neither gray nor blue.
The early SSM is a thinly raised plaque with a comparatively uniform border and a remarkable range of colors, including tan, brown, black, and even red or white.
 Excision is the method of treatment.