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Differential Diagnosis of General Causes of Megaloblastic Anemia
• Congenital disorders of DNA synthesis (rare): orotic aciduria, Lesch-Nyhan syndrome, congenital dyserythropoietic anemia
• Acquired disorders of DNA synthesis: thiamine-responsive megaloblastosis (rare); malignant neoplasia, erythroleukemia, refractory sideroblastic anemias; all antineoplastic drugs that inhibit DNA synthesis; toxic alcohol
• Congenital disorders of DNA synthesis (rare): orotic aciduria, Lesch-Nyhan syndrome, congenital dyserythropoietic anemia
• Acquired disorders of DNA synthesis: thiamine-responsive megaloblastosis (rare); malignant neoplasia, erythroleukemia, refractory sideroblastic anemias; all antineoplastic drugs that inhibit DNA synthesis; toxic alcohol
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