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Differential Diagnosis of Hemolytic Autoimmune Anemia • Nonimmune mediated: microangiopathic hemolytic anemia, hypersplenism, cardiac valve prosthesis, giant cavernous hemangiomas, march hemoglobinuria, physical agents, infections, heavy metals, drugs (nitrofurantoin, sulfonamides) • Hemolytic anemia caused by membrane defects: paroxysmal nocturnal hemoglobinuria, spur cell anemia, Wilson’s disease 
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