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Differential Diagnosis of Respiratory Acidosis • Thoracic cage disorders (pneumothorax, flail chest, kyphoscoliosis) • Pulmonary disease (chronic obstructive pulmonary disease [COPD], severe pneumonia, pulmonary edema, interstitial fibrosis) • Failure of mechanical ventilator • Depression of respiratory center (anesthesia, narcotics, sedatives, vertebral artery embolism or thrombosis, increased intracranial pressure) • Defects in peripheral nervous system (amyotrophic lateral sclerosis, poliomyelitis, Guillain-Barré syndrome, botulism, tetanus, organophosphate poisoning, spinal cord injury) • Defects in muscles of respiration (myasthenia gravis, hypokalemia, muscular dystrophy) • Airway obstruction (foreign body, severe bronchospasm, laryngospasm) 
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