​Infectious Diseases and Microbiology - Aseptic Meningitis ( Coxsackieviruses and echoviruses)

​Infectious Diseases and Microbiology - Aseptic Meningitis ( Coxsackieviruses and echoviruses) 
Aseptic meningitis is frequently caused by nonpolio enteroviruses, such as coxsackieviruses and echoviruses. The fecal-oral route and direct contact with contaminated secretions are the two main ways that coxsackie and echoviruses spread; respiratory droplets are less frequently used. In temperate regions, the summer and fall months are when coxsackie and echovirus infections are most prevalent. Every virus has a variety of serotypes.
The symptoms of clinical aseptic meningitis include photophobia, stiff neck, headache, and sudden start of fever. Most people recover completely without any CNS after approximately a week. Additional illness syndromes linked to coxsackieviruses and echoviruses include acute hemorrhagic conjunctivitis (coxsackie A), hand-foot-and-mouth disease (coxsackie A), pleurodynia and myalgia (coxsackie B), and pericarditis and myocarditis (coxsackie B).

The pathophysiology of coxsackievirus and echovirus is comparable to that of poliovirus, but they vary in that they typically infect the meninges as opposed to the motor neurons. Target cells are directly harmed and killed by the virus.
Viral clearance is mediated by antibodies.

PCR is used for the detection and differentiation of coxsackieviruses and echoviruses.
Diagnosis: Treatment for coxsackie or echovirus infection is nonexistent, nor is there a vaccination. Regular hand washing and avoiding sharing bedding and towels with those who have conjunctivitis are two preventative methods.