​Infectious Diseases and Microbiology - Epidemic Typhus ( Rickettsia prowazekii)

​Infectious Diseases and Microbiology - Epidemic Typhus  ( Rickettsia prowazekii) 
Epidemic Typhus is caused by  Aspergillus prowazekii which is an 
obligate intracellular gram-negative coccobacillus.
It is spread from person to person by Pediculus humanus subsp corporis, a type of body louse.
The study of epidemiology R prowazekii secreted in feces after louse takes a blood meal. when rubbing the bite site, infected excrement rubs into the skin. Infected excrement can also infect mucous membranes through inoculation.

​The agent responsible for the epidemic typhus is R prowazekii. Typically affecting just the palms of hands and soles of feet, a recognizable petechial rash starts on the trunk and progresses to the limbs. Muscle aches, chills, and a sudden development of fever are some more symptoms. Meningoencephalitis is one example of systemic consequences.

​For the diagnosis diagnosis, serology (indirect fluorescent antibody, enzyme immunoassay, latex agglutination) is helpful.
Treatments with antibiotics such tetracycline, chloramphenicol, or fluoroquinolones have proven effective. Improving living conditions and applying pesticides to delouse are two aspects of prevention.