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Pathology - Acinar Cell Carcinoma
Definition: A malignant epithelial tumor in the pancreas that produces enzymes.
Epidemiology • This rare tumor accounts for around 1% of all pancreatic tumors. • The majority occur in older persons.
Aetiology: unknown. Carcinogenesis has been linked to abnormalities in the APC/B-catenin pathway.
• Genetic alterations common in ductal adenocarcinoma are missing.
Presentation: General symptoms include stomach pain, weight loss, nausea, and diarrhea. • Approximately 10% of individuals experience polyarthralgia and multifocal fat necrosis due to lipase secretion.
Macroscopy reveals a well-defined soft tan tumor in the pancreas. • An extension outside the pancreas may be present. Histopathology • Neoplastic epithelial cells form in sheets, trabeculae, and acini. • Some cells have eosinophilic finely granular cytoplasm.
• Immunoreactivity for lipase, trypsin, and chymotrypsin is positive.
Prognosis: Aggressive malignant tumors. • The median survival time following diagnosis is 18 months, with a 5-year survival rate of
Definition: A malignant epithelial tumor in the pancreas that produces enzymes.
Epidemiology • This rare tumor accounts for around 1% of all pancreatic tumors. • The majority occur in older persons.
Aetiology: unknown. Carcinogenesis has been linked to abnormalities in the APC/B-catenin pathway.
• Genetic alterations common in ductal adenocarcinoma are missing.
Presentation: General symptoms include stomach pain, weight loss, nausea, and diarrhea. • Approximately 10% of individuals experience polyarthralgia and multifocal fat necrosis due to lipase secretion.
Macroscopy reveals a well-defined soft tan tumor in the pancreas. • An extension outside the pancreas may be present. Histopathology • Neoplastic epithelial cells form in sheets, trabeculae, and acini. • Some cells have eosinophilic finely granular cytoplasm.
• Immunoreactivity for lipase, trypsin, and chymotrypsin is positive.
Prognosis: Aggressive malignant tumors. • The median survival time following diagnosis is 18 months, with a 5-year survival rate of
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