​Pathology - Anti-glomerular Basement Membrane Disease, or Goodpasture Syndrome

​Pathology - Anti-glomerular Basement Membrane Disease, or Goodpasture Syndrome
Goodpasture syndrome, another name for anti-glomerular basement membrane illness, is a condition in which autoantibodies are produced against a type IV collagen antigen and cross-react with both the pulmonary alveoli and the glomerular basement membrane. This is known as Goodpasture syndrome when there is acute damage to both the kidney and lung, as it is in this case.
It is more likely in older people to experience isolated renal involvement. Although the exact cause of autoimmunity is unknown, an infection may be the catalyst; HLA DR15 and DR4 positive people are more susceptible. The majority of cases of hemoptysis are in smokers. The vital signs of this patient show a substantial pulmonary hemorrhage. Rapid and potentially lethal pulmonary bleeding and renal function decrease are possible outcomes. The staging of renal crescents on biopsy is important because it demonstrates that, as opposed to growing gradually from a different cause, they all formed at the same moment the anti-GBM antibodies first appeared. The glomerular basement membrane likewise exhibits a linear pattern when stained with immunofluorescence. Before the invention of immunosuppressive medications and plasma exchange, the prognosis for Goodpasture syndrome was extremely bad.