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Pathology - Atopic Dermatitis (Eczema)
The precise cause of the condition is unknown, but immune system failure that results in IgE sensitization and subsequent epithelial inflammation has been theorized. The condition is frequently linked to a personal or familial history of allergies, asthma, or atopic dermatitis.
Most frequently manifests in youngsters under the age of four.
Depending on the stage of the illness, may show multiple histopathologic skin appearances (similar to allergic contact dermatitis).
Acute stage: perivascular lymphocytic infiltration in epidermis; vesicles; edema fluid within epidermis (spongiosis).
Subacute stage: Acute and chronic characteristics combined.
Chronic stage: dermal lymphocytic infiltration, hyperkeratosis, and anaanthosis.
Prickly lesion episodes can be crusty, scaly, or exudative; they typically affect the hands, upper trunk, antecubital and popliteal folds, and the face (particularly the area around the eyes). In the event that the episodes are prolonged, the skin may thicken (lichenify) and produce dry, scaly patches.
Results of the lab: elevated IgE levels or eosinophilia may be observed.
Handling
Antihistamines, moisturizers, and topical corticosteroids are used to treat pruritus.
The precise cause of the condition is unknown, but immune system failure that results in IgE sensitization and subsequent epithelial inflammation has been theorized. The condition is frequently linked to a personal or familial history of allergies, asthma, or atopic dermatitis.
Most frequently manifests in youngsters under the age of four.
Depending on the stage of the illness, may show multiple histopathologic skin appearances (similar to allergic contact dermatitis).
Acute stage: perivascular lymphocytic infiltration in epidermis; vesicles; edema fluid within epidermis (spongiosis).
Subacute stage: Acute and chronic characteristics combined.
Chronic stage: dermal lymphocytic infiltration, hyperkeratosis, and anaanthosis.
Prickly lesion episodes can be crusty, scaly, or exudative; they typically affect the hands, upper trunk, antecubital and popliteal folds, and the face (particularly the area around the eyes). In the event that the episodes are prolonged, the skin may thicken (lichenify) and produce dry, scaly patches.
Results of the lab: elevated IgE levels or eosinophilia may be observed.
Handling
Antihistamines, moisturizers, and topical corticosteroids are used to treat pruritus.
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