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Pathology - Autoimmune Hepatitis
Autoimmune disease frequently co-occurs with other autoimmune disorders.
Sjogren's syndrome, thyroiditis, ulcerative colitis, and arthritis.
Most prevalent in young ladies but can impact individuals of various ages.
Pathology
Pathological findings: Liver showing cirrhosis with fibrous septa and nodular structure
Microscopic findings include bridging fibrosis in the portal and periportal areas, as well as hepatocyte necrosis.
May have no symptoms at first or may show signs of acute hepatitis, jaundice, enlarged liver, spider nevi, and absence of menstruation Laboratory results: Increased -globulin levels, raised bilirubins and transaminases, positive antinuclear antibody (ANA), positive anti-smooth muscle antibody (ASMA) type 1, positive anti-liver kidney microsomal antibody (anti-LKM-1) type 2.
Treatment: Prednisone with or without azathioprine may be used. Liver transplant should be considered for patients with severe cirrhosis.
Autoimmune disease frequently co-occurs with other autoimmune disorders.
Sjogren's syndrome, thyroiditis, ulcerative colitis, and arthritis.
Most prevalent in young ladies but can impact individuals of various ages.
Pathology
Pathological findings: Liver showing cirrhosis with fibrous septa and nodular structure
Microscopic findings include bridging fibrosis in the portal and periportal areas, as well as hepatocyte necrosis.
May have no symptoms at first or may show signs of acute hepatitis, jaundice, enlarged liver, spider nevi, and absence of menstruation Laboratory results: Increased -globulin levels, raised bilirubins and transaminases, positive antinuclear antibody (ANA), positive anti-smooth muscle antibody (ASMA) type 1, positive anti-liver kidney microsomal antibody (anti-LKM-1) type 2.
Treatment: Prednisone with or without azathioprine may be used. Liver transplant should be considered for patients with severe cirrhosis.
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