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Pathology - Basal Cell Carcinoma
The most prevalent type of skin tumor.
Fair skin, long-term immunosuppression, prolonged sun exposure, and compromised DNA repair systems (such as xeroderma pigmentosum) are risk factors.
Skin: Nodular, cystic, and trabecular development patterns; tumor clumps surrounded by cells at the periphery with palisading nuclei; clusters of atypical tumor cells with dark blue nuclei emerging from epidermal basal cells; invades dermis.
Pearly, dome-shaped, telangiectatic papule that typically appears on sun-exposed areas (particularly the face and neck); may bleed or ulcerate; may have a rolling border surrounding a centrally depressed center.
Handling
surgical removal.
Surgery is usually curative since it seldom metastasizes.
Xeroderma pigmentosum is a condition that is recessive in nature. It is typified by mutations in the genes responsible for nucleotide excision repair, which is required to fix pyrimidine dimers created by exposure to UV light. An elevated incidence of all forms of skin cancer is one of the clinical symptoms.
The most prevalent type of skin tumor.
Fair skin, long-term immunosuppression, prolonged sun exposure, and compromised DNA repair systems (such as xeroderma pigmentosum) are risk factors.
Skin: Nodular, cystic, and trabecular development patterns; tumor clumps surrounded by cells at the periphery with palisading nuclei; clusters of atypical tumor cells with dark blue nuclei emerging from epidermal basal cells; invades dermis.
Pearly, dome-shaped, telangiectatic papule that typically appears on sun-exposed areas (particularly the face and neck); may bleed or ulcerate; may have a rolling border surrounding a centrally depressed center.
Handling
surgical removal.
Surgery is usually curative since it seldom metastasizes.
Xeroderma pigmentosum is a condition that is recessive in nature. It is typified by mutations in the genes responsible for nucleotide excision repair, which is required to fix pyrimidine dimers created by exposure to UV light. An elevated incidence of all forms of skin cancer is one of the clinical symptoms.
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