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Pathology - Benign Prostatic Hyperplasia
Symptoms are related to involvement of the periurethral prostatic tissue; alternatively, prostate tumors might be asymptomatic if they start in the peripheral prostatic tissue. Dihydrotestosterone (DHT) causes hyperplasia of the glandular cells. Estrogen also has a role by upregulating androgen receptors.
5-Alpha-reductase inhibitors like as finasteride, which prevent synthesis of DHT from testosterone in stromal cells, can be utilized in the treatment of BPH. Irregular and nodular prostates should undergo biopsy to rule out prostate cancer.
It is vital to note that PSA might be increased in BPH and prostatitis.
Symptoms are related to involvement of the periurethral prostatic tissue; alternatively, prostate tumors might be asymptomatic if they start in the peripheral prostatic tissue. Dihydrotestosterone (DHT) causes hyperplasia of the glandular cells. Estrogen also has a role by upregulating androgen receptors.
5-Alpha-reductase inhibitors like as finasteride, which prevent synthesis of DHT from testosterone in stromal cells, can be utilized in the treatment of BPH. Irregular and nodular prostates should undergo biopsy to rule out prostate cancer.
It is vital to note that PSA might be increased in BPH and prostatitis.
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