​Pathology - Celiac Disease

​Pathology - Celiac Disease
Pathophysiology 
Another name for it is celiac sprue. Autoantibodies to gluten are the source of an autoimmune disorder, which can manifest in early childhood or early adulthood. A protein called gluten can be found in grains like barley, rye, and oats. According to the patient's laboratory results, the disease's physical signs are caused by the flattening of villous processes in the small intestine, which destroys the natural architecture of villous cells and severely impairs the body's ability to absorb iron, lipids, and vitamin B12. Since the distal ileum is typically where vitamin B12 is absorbed and the duodenum is where iron is primarily absorbed, the presence of malabsorption of both chemicals suggests broad small bowel involvement. Dermatitis herpetiformis, which typically manifests on extensor surfaces, is closely linked to celiac disease.
Symptoms will improve if gluten-containing goods are avoided.