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Pathology - Chronic Myelogenous Leukemia
The symptoms arise as a result of underlying abnormalities in the blood, including infection caused by faulty white blood cell function, and reduced energy due to anemia. Increased proliferation of leukemic cells within the bone marrow can cause bone pain to arise later in the disease. Chronic Myeloid Leukemia (CML) is a result of a genetic rearrangement that occurs between chromosomes 9 and 22, known as the Philadelphia chromosome. The translocation event results in the creation of the BCR-ABL fusion protein, which serves as a target for some chemotherapeutic medications like Imatinib, a type of tyrosine kinase inhibitor. Chronic myeloid leukemia (CML) can be distinguished from other forms of leukemia by the presence of a higher quantity of platelets, a characteristic that is not commonly observed in other types of leukemia.
The leukemoid reaction, which is characterized by an increased white blood cell count in response to infection or stress, can be differentiated from chronic myelogenous leukemia (CML) by observing the rise in leukocyte alkaline phosphatase score in the non-cancerous cells of the leukemoid reaction.
The symptoms arise as a result of underlying abnormalities in the blood, including infection caused by faulty white blood cell function, and reduced energy due to anemia. Increased proliferation of leukemic cells within the bone marrow can cause bone pain to arise later in the disease. Chronic Myeloid Leukemia (CML) is a result of a genetic rearrangement that occurs between chromosomes 9 and 22, known as the Philadelphia chromosome. The translocation event results in the creation of the BCR-ABL fusion protein, which serves as a target for some chemotherapeutic medications like Imatinib, a type of tyrosine kinase inhibitor. Chronic myeloid leukemia (CML) can be distinguished from other forms of leukemia by the presence of a higher quantity of platelets, a characteristic that is not commonly observed in other types of leukemia.
The leukemoid reaction, which is characterized by an increased white blood cell count in response to infection or stress, can be differentiated from chronic myelogenous leukemia (CML) by observing the rise in leukocyte alkaline phosphatase score in the non-cancerous cells of the leukemoid reaction.
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