​Pathology-Crohn's disease

​Pathology-Crohn's disease
idiopathic, despite the possibility of infectious origins
most common in women between the ages of 15 and 30.

Gross Pathology: Changes to the colon, small intestine, and terminal ileum; absent from the rectum: creeping fat across the surface of the gut. Cobblestone mucosa submucosal edema with elevation of surviving mucosa; thickened bowel wall resulting in a constricted lumen and linear ulceration of the mucosa).
Microscopic Pathology : Skip lesions, or sections of healthy bowel mixed with diseased bowel, are indicative of transmural inflammation. fissures: noncaseating granulomas: crvpt atronhv: metaplasia of the mucosa
sporadic episodes of low-grade fever diarrhea, frequently accompanied by blood and pain in the right lower quadrant: physical examination may reveal a mass in this area.
Extraintestinal  manitestations: Oral apthous ulcer,migrant polyarthritis; uveitis: ankylosing spondylitis; sacroilitis: ankylosing spondylitis
Complications include perianal fistulas and abscesses, malabsorption syndrome, and fibrous strictures that result in intestinal blockage or perforation.

Imaging: Evidence of ulceration, stricturing, or fistulas of the small intestine or colon on endoscopy; string sign on x-ray following barium swallow (represents constricted gut lumen).
Immunomodulators, glucocorticoids, sulfasalazine, antidiarrheals, and surgery as necessary to repair fistulas or obstructons 
Crohn's disease and ulcerative colitis are classified as inflammatory bowel diseases.