Pathology - Cryoglobulinemia
Possible causes encompass lymphoproliferative illnesses such as multiple myeloma, chronic lymphocytic leukemia (CLL), and non-Hodgkin lymphoma (NHL), as well as hepatitis C virus (HCV) infection. The causes of autoimmune syndromes can be attributed to infections such as Epstein-Barr virus (EBV) or cytomegalovirus (CMV), or they can occur without a known cause (idiopathic). Primarily impacts women in their middle age Study of the nature and causes of diseases. Gross Pathology: Impacts the smaller blood arteries, specifically arterioles, capillaries, and venules, with a particular emphasis on the skin and kidneys. Study of cellular and tissue abnormalities at a microscopic level: Vasculitis characterized by the presence of cryoglobulin immunological deposits causing inflammation of the vascular wall. Symptoms and signs Symptoms include weakness, livedo reticularis, visible purpura, arthralgias, and glomerulonephritis with nephritic syndrome. Anemia: Peripheral neuropathy causes stomach pain. Laboratory results: Positive cryocrit result. Reduced amounts of C4 Therapy Address the root cause of the problem; provide steroids or other immunosuppressant medications to manage complications affecting internal organs.
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