- Published on
Pathology - Erectile Dysfunction
Two mediators in penile tumescence are nitric oxide (NO) and cyclic guanosine monophosphate (GMP). Tactile stimulation of the penis leads in the firing of neurons that transfer impulses based on feeling. This produces secretion of NO which has a vasodilatory effect, allowing corpora cavernosa to engorge with blood. Cyclic GMP also has a vasodilatory impact. Disorders that alter brain function, such diabetes, can influence a patient’s ability to obtain an erection. There are various more factors that can cause erectile dysfunction that should be considered: psychogenic disorders, drug use, vasculopathy, and endocrine abnormalities. With psychogenic difficulties, patients still tend to have morning tumescence after waking from REM sleep. The current gold standard treatment is oral phosphodiesterase inhibitors, which function by inhibiting the breakdown of cyclic GMP.
Two mediators in penile tumescence are nitric oxide (NO) and cyclic guanosine monophosphate (GMP). Tactile stimulation of the penis leads in the firing of neurons that transfer impulses based on feeling. This produces secretion of NO which has a vasodilatory effect, allowing corpora cavernosa to engorge with blood. Cyclic GMP also has a vasodilatory impact. Disorders that alter brain function, such diabetes, can influence a patient’s ability to obtain an erection. There are various more factors that can cause erectile dysfunction that should be considered: psychogenic disorders, drug use, vasculopathy, and endocrine abnormalities. With psychogenic difficulties, patients still tend to have morning tumescence after waking from REM sleep. The current gold standard treatment is oral phosphodiesterase inhibitors, which function by inhibiting the breakdown of cyclic GMP.
0 Comments
