- Published on
Pathology - Erythema nodosum
A syndrome clinically defined by an acute, painful, erythematous nodular skin eruption and histologically characterized by septal panniculitis. Epidemiology • Primarily impacts young adults, with a significant inclination towards women.
Aetiology • Various aetiologies have been identified. • The most prevalent associations include sarcoidosis, infections, inflammatory bowel disease and pharmaceuticals. Pathogenesis • Etiology is unclear, but likely constitutes a type of hypersensitive reaction to infection, medication, or an underlying systemic disorder.
Presentation • Abrupt emergence of erythematous, warm, and sensitive cutaneous nodules. • Typically affects the shins, though other areas may be involved. • Systemic manifestations, including fever and malaise, may also occur. Histopathology • Biopsies reveal septal panniculitis marked by an inflammatory infiltrate localized to the septa of the subcutaneous adipose tissue. • The inflammatory infiltrate primarily consists of lymphocytes and macrophages. • Aggregates of histiocytes encircled by cleft-like spaces are well-documented (Mieschner’s radial granuloma).
Prognosis: The ailment typically resolves spontaneously within weeks, with the skin nodules ultimately diminishing and discoloring similarly to a bruise.
A syndrome clinically defined by an acute, painful, erythematous nodular skin eruption and histologically characterized by septal panniculitis. Epidemiology • Primarily impacts young adults, with a significant inclination towards women.
Aetiology • Various aetiologies have been identified. • The most prevalent associations include sarcoidosis, infections, inflammatory bowel disease and pharmaceuticals. Pathogenesis • Etiology is unclear, but likely constitutes a type of hypersensitive reaction to infection, medication, or an underlying systemic disorder.
Presentation • Abrupt emergence of erythematous, warm, and sensitive cutaneous nodules. • Typically affects the shins, though other areas may be involved. • Systemic manifestations, including fever and malaise, may also occur. Histopathology • Biopsies reveal septal panniculitis marked by an inflammatory infiltrate localized to the septa of the subcutaneous adipose tissue. • The inflammatory infiltrate primarily consists of lymphocytes and macrophages. • Aggregates of histiocytes encircled by cleft-like spaces are well-documented (Mieschner’s radial granuloma).
Prognosis: The ailment typically resolves spontaneously within weeks, with the skin nodules ultimately diminishing and discoloring similarly to a bruise.
0 Comments
