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Pathology - Ewing Sarcoma
connected to the translocation t of the chromosome (11, 22), resulting in the formation of the fusion protein EWS-FL/1, a super-activated transcriptional factor.
classified as a little, spherical, blue tumor; the source of the tumor cells is uncertain.
Most common in males under the age of twenty.
Pathology
Gross: Usually develops in the scapula, pelvis, ribs, and medullary cavities of long bones.
Microscopic: Necrosis may be seen; tumor cells may be organized in a pseudorosette pattern. Sheets of tiny, spherical, blue, homogenous cells with minimal cytoplasm.
Clinical Symptoms and Signs
painful, enlarged, expanding mass; may exhibit systemic symptoms such as fever and anemia (may resemble symptoms of osteomyelitis); may occur with pathological fracture.
As a result, there may be lung, lymph node, or infrequently, central nervous system metastases.
Imaging: On a radiograph, a lymphatic tumor resembles an onion.
Interventions
radiation, chemotherapy, and surgical resection.
An very aggressive tumor with a 70% 5-year survival rate for localized disease and less than 30% for metastatic disease is prone to metastasis early.
connected to the translocation t of the chromosome (11, 22), resulting in the formation of the fusion protein EWS-FL/1, a super-activated transcriptional factor.
classified as a little, spherical, blue tumor; the source of the tumor cells is uncertain.
Most common in males under the age of twenty.
Pathology
Gross: Usually develops in the scapula, pelvis, ribs, and medullary cavities of long bones.
Microscopic: Necrosis may be seen; tumor cells may be organized in a pseudorosette pattern. Sheets of tiny, spherical, blue, homogenous cells with minimal cytoplasm.
Clinical Symptoms and Signs
painful, enlarged, expanding mass; may exhibit systemic symptoms such as fever and anemia (may resemble symptoms of osteomyelitis); may occur with pathological fracture.
As a result, there may be lung, lymph node, or infrequently, central nervous system metastases.
Imaging: On a radiograph, a lymphatic tumor resembles an onion.
Interventions
radiation, chemotherapy, and surgical resection.
An very aggressive tumor with a 70% 5-year survival rate for localized disease and less than 30% for metastatic disease is prone to metastasis early.
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