Pathology - Fat tissue necrosis

Pathology - Fat tissue necrosis
Definition: An inflammatory response to injured adipose tissue. Epidemiology: Prevalent. Aetiology: Trauma to the breast. • Following surgical intervention or radiation. Pathogenesis • Compromised adipocytes release their lipid contents, provoking an inflammatory response that leads to the formation of a palpable mass.

Presentation • The majority present with a breast mass that is firm and indurated.Can closely resemble breast carcinoma in clinical presentation. Macroscopy • The breast tissue exhibits yellow-white flecks of discolouration. Cytopathology: FNA cytology reveals foamy macrophages, multinucleated large cells, and background detritus. Histopathology: Degenerating adipocytes are observed, encircled by foamy macrophages, multinucleated giant cells, lymphocytes, and plasma cells. Subsequent alterations encompass fibrosis and calcification.

Prognosis: Benign with no elevated risk of breast cancer.