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Pathology - Granuloma annulare
Definition: An inflammatory dermatosis often characterized by annular lesions clinically and necrobiotic granulomatous inflammation histologically.
Epidemiology: Prevalent. Aetiology • Predominantly unknown in most instances. • Borrelia infection has been associated with a limited number of instances.
Pathogenesis • Current information indicates it constitutes a cutaneous reaction pattern to undefined antigens.
Presentation • Localized lesions of granuloma annulare manifest as flesh-colored or red papules that coalesce to form an annular lesion of 1–5 cm. • Acral regions are typically involved, particularly the knuckles and fingers.
Histopathology • The dermis exhibits a palisading granuloma, defined by a core region of degraded (necrobiotic) collagen encircled by radially oriented histiocytes, lymphocytes, and fibroblasts. • Mucin is frequently observed within the necrobiotic focal area. • Sometimes, the process results in a more nuanced ill-defined lesion in the dermis instead of a conventional well-formed palisaded granuloma (interstitial granuloma annulare).
Prognosis: Approximately 50% of cases resolve after two years of commencement, however recurrences are rather frequent.
Definition: An inflammatory dermatosis often characterized by annular lesions clinically and necrobiotic granulomatous inflammation histologically.
Epidemiology: Prevalent. Aetiology • Predominantly unknown in most instances. • Borrelia infection has been associated with a limited number of instances.
Pathogenesis • Current information indicates it constitutes a cutaneous reaction pattern to undefined antigens.
Presentation • Localized lesions of granuloma annulare manifest as flesh-colored or red papules that coalesce to form an annular lesion of 1–5 cm. • Acral regions are typically involved, particularly the knuckles and fingers.
Histopathology • The dermis exhibits a palisading granuloma, defined by a core region of degraded (necrobiotic) collagen encircled by radially oriented histiocytes, lymphocytes, and fibroblasts. • Mucin is frequently observed within the necrobiotic focal area. • Sometimes, the process results in a more nuanced ill-defined lesion in the dermis instead of a conventional well-formed palisaded granuloma (interstitial granuloma annulare).
Prognosis: Approximately 50% of cases resolve after two years of commencement, however recurrences are rather frequent.
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