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Pathology - Guillain-Barré Syndrome
Pathophysiology
Peripheral demyelinating disease is known as Guillain-Barré syndrome (GBS). Usually, these individuals arrive with rapidly developing ascending paralysis. The disease's genesis is believed to be autoimmune, and several cases have been linked to different gastrointestinal tract illnesses. Given the patient's history of diarrhea and abdominal pain, Campylobacter jejuni is the most often encountered infection linked to GBS. The CSF analysis, which demonstrates albuminocytologic dissociation, is the cornerstone of the diagnostic assessment. This indicates that although the cell count is within the normal range, the protein is high. It is best to exclude out infectious etiologies if the cell count is increased. In order to treat GBS, either quick plasmapheresis to eliminate antibodies or IVIG injection to bind antibodies are necessary.
Pathophysiology
Peripheral demyelinating disease is known as Guillain-Barré syndrome (GBS). Usually, these individuals arrive with rapidly developing ascending paralysis. The disease's genesis is believed to be autoimmune, and several cases have been linked to different gastrointestinal tract illnesses. Given the patient's history of diarrhea and abdominal pain, Campylobacter jejuni is the most often encountered infection linked to GBS. The CSF analysis, which demonstrates albuminocytologic dissociation, is the cornerstone of the diagnostic assessment. This indicates that although the cell count is within the normal range, the protein is high. It is best to exclude out infectious etiologies if the cell count is increased. In order to treat GBS, either quick plasmapheresis to eliminate antibodies or IVIG injection to bind antibodies are necessary.
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