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Pathology - Klinefelter Syndrome
Causes (most typically 47, XXY karyotype with a single Barr body) when two or more X chromosomes combine with one or more Y chromosomes.
This genetic condition can be caused by paternal or maternal meiotic nondisjunction, but its incidence increases with maternal age. Maternal meiotic nondisjunction is the most prevalent cause of this disorder.
Tall stature; atrophic, small testes; gynecomastia and absence of secondary masculine traits; male infertility, frequently due to decreased spermatogenesis; higher rate of venous ulcers; infrequently linked to minor developmental delay.
Results of the lab: elevated levels of FSH and LH, decreased levels of testosterone.
Treatment: Start replacing testosterone when a teen reaches puberty; does not address infertility.
Tall guys with severe acne are associated with XYY syndrome. Criminals are more likely to experience XYY syndrome.
Causes (most typically 47, XXY karyotype with a single Barr body) when two or more X chromosomes combine with one or more Y chromosomes.
This genetic condition can be caused by paternal or maternal meiotic nondisjunction, but its incidence increases with maternal age. Maternal meiotic nondisjunction is the most prevalent cause of this disorder.
Tall stature; atrophic, small testes; gynecomastia and absence of secondary masculine traits; male infertility, frequently due to decreased spermatogenesis; higher rate of venous ulcers; infrequently linked to minor developmental delay.
Results of the lab: elevated levels of FSH and LH, decreased levels of testosterone.
Treatment: Start replacing testosterone when a teen reaches puberty; does not address infertility.
Tall guys with severe acne are associated with XYY syndrome. Criminals are more likely to experience XYY syndrome.
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