​Pathology- Medulloblastoma

​Pathology- Medulloblastoma 
Malignant tumor originating in the cerebellum, linked to a deletion on the short arm of chromosome 17 (17p-).
Primarily found in youngsters and represents 20% of all brain tumors in this age group.


The tumor is gray, well-defined, and situated at the midline of the cerebellum.
Microscopic examination reveals densely packed sheets of undifferentiated cells with numerous divisions, minimal cytoplasm, and intensely stained nuclei. The cells are frequently organized in a circular or pseudo-circular pattern around blood vessels.

Unstable walking; blockage of cerebrospinal fluid flow due to tumor compressing the fourth ventricle leading to obstructive hydrocephalus; seizures, headaches; nausea, vomiting; and other symptoms of elevated intracranial pressure.

Therapy Surgical intervention combined with radiation and chemotherapy.
The 5-year survival rate is 75% with complete removal of the tumor plus radiation therapy.