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Pathology. - Minimal change disease
Definition: A glomerulopathy with clinical symptoms of nephrotic syndrome and histologically normal glomeruli under light microscopy.
Epidemiology • Uncommon. • Most commonly seen in children aged 2-6 years, but can also affect adults. The exact reason is unknown, however recent data shows it may be due to immunological malfunction. • Research has shown that minimal change disease (MCD) can occur after exposure to drugs, bee stings, or venom.
Pathogenesis: • The podocyte is assumed to be the primary cell involved in MCD. • Normal podocyte activity is compromised, making the glomerular filtration barrier abnormally permeable to proteins.
Presentation: • Nephrotic syndrome. Light microscopy shows typical glomeruli. immune fluorescence • No specific immune deposition is present.
Electron microscopy reveals that podocyte foot processes are highly simplified and lack immune complexes.
Prognosis: • MCD typically results in full recovery, especially in youngsters. Adults with steroid-resistant disease should be closely watched as they may have FSGS (b p. 148) that was not detected during biopsy due to its focused character.
Definition: A glomerulopathy with clinical symptoms of nephrotic syndrome and histologically normal glomeruli under light microscopy.
Epidemiology • Uncommon. • Most commonly seen in children aged 2-6 years, but can also affect adults. The exact reason is unknown, however recent data shows it may be due to immunological malfunction. • Research has shown that minimal change disease (MCD) can occur after exposure to drugs, bee stings, or venom.
Pathogenesis: • The podocyte is assumed to be the primary cell involved in MCD. • Normal podocyte activity is compromised, making the glomerular filtration barrier abnormally permeable to proteins.
Presentation: • Nephrotic syndrome. Light microscopy shows typical glomeruli. immune fluorescence • No specific immune deposition is present.
Electron microscopy reveals that podocyte foot processes are highly simplified and lack immune complexes.
Prognosis: • MCD typically results in full recovery, especially in youngsters. Adults with steroid-resistant disease should be closely watched as they may have FSGS (b p. 148) that was not detected during biopsy due to its focused character.
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