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Pathology – Neoplasia
Definitions
A neoplasm is an abnormal tissue mass characterized by unregulated growth and lacking any beneficial function. The term is frequently employed interchangeably with the term tumor, which denotes a swelling.

Benign neoplasms typically have a gradual development rate and remain localized to their site of origin. While benign neoplasms typically follow a harmless trajectory, they may pose risks if they exert pressure on essential adjacent structures or if they emit hormones indiscriminately.
Malignant neoplasms possess the ability to disseminate or metastasis to remote locations, resulting in new tumors known as metastases, which can proliferate independently of the initial tumor.
Cancer is an overarching word for any malignant neoplasm.
Nomenclature of neoplasms
Epithelial neoplasms
Benign neoplasms of squamous epithelium are termed acanthomas when flat and papillomas when exhibiting branching fronds.
Benign neoplasms of glandular epithelium are referred to as adenomas.
Epithelial malignancies are classified as carcinomas.
Carcinomas exhibiting squamous differentiation are termed squamous cell carcinomas. Carcinomas exhibiting glandular differentiation are termed adenocarcinomas. Carcinomas frequently follow a stage of epithelial dysplasia, characterized by the presence of neoplastic cells inside the epithelium, without penetration beyond the epithelial boundaries.

Neoplasms of connective tissue Lipoma is a benign adipose tissue tumor. • Leiomyoma is a benign neoplasm of smooth muscle. • Rhabdomyoma is a benign neoplasm of skeletal muscle. • Angioma is a benign vascular neoplasm. • Osteoma is a benign osseous neoplasm. Liposarcoma is a malignant tumor of adipose tissue. Leiomyosarcoma is a malignant neoplasm of smooth muscle tissue. • Rhabdomyosarcoma is a malignant neoplasm of skeletal muscle. • Angiosarcoma is a malignant neoplasm of vascular tissue. • Osteosarcoma is a malignant neoplasm of bone.
Alternative neoplasm classifications Lymphomas, leukemias, and myeloma are hematological malignancies originating from blood or bone marrow cells.
Malignant melanoma is a tumor of malignant melanocytes. Malignant mesothelioma is a neoplastic mesothelial tumor. Germ cell tumors constitute a heterogeneous category of neoplasms that typically originate in the testes or ovaries. Embryonal tumors are a category of malignant neoplasms primarily observed in children, characterized by highly undifferentiated cells, such as neuroblastoma and nephroblastoma.


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