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Pathology - Pick Disease
The cause is unidentified, but there is evidence suggesting that mutations on chromosomes 3, 9, and 17 are inherited in an autosomal dominant manner in up to 50% of cases.
Pathology: Uneven shrinkage of the frontal and temporal lobes of the brain.
Microscopic examination reveals the presence of Pick cells, which are enlarged neurons, or Pick bodies, which are spherical, silver-staining, neurofilamentous entities present in the cytoplasm within neurons.
Symptoms and signs
Dementia manifests with predominant personality changes, atypical behavioral patterns, and speech problems.
Therapies
Address symptoms; handle behavioral issues.
Chronic illness with no remedy.
Dementia with Lewy bodies is a progressive form of dementia characterized by parkinsonism and hallucinations. Histologically, it is identified by the presence of Lewy bodies, which are eosinophilic inclusion bodies found in the cytoplasm of substantia nigra cells.
The cause is unidentified, but there is evidence suggesting that mutations on chromosomes 3, 9, and 17 are inherited in an autosomal dominant manner in up to 50% of cases.
Pathology: Uneven shrinkage of the frontal and temporal lobes of the brain.
Microscopic examination reveals the presence of Pick cells, which are enlarged neurons, or Pick bodies, which are spherical, silver-staining, neurofilamentous entities present in the cytoplasm within neurons.
Symptoms and signs
Dementia manifests with predominant personality changes, atypical behavioral patterns, and speech problems.
Therapies
Address symptoms; handle behavioral issues.
Chronic illness with no remedy.
Dementia with Lewy bodies is a progressive form of dementia characterized by parkinsonism and hallucinations. Histologically, it is identified by the presence of Lewy bodies, which are eosinophilic inclusion bodies found in the cytoplasm of substantia nigra cells.
Pick Disease / Frontotemporal Dementia
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