Pathology - Psoriasis
Although there have been theories regarding autoimmune processes and hereditary risk, the etiology is unknown. Skin: Neutrophil clusters in the stratum corneum (Munro microabscesses) or the epidermis (spongiform pustules); thinning of the surface epidermis over dermal papillae, resulting in the proximity of dermal blood vessels to the surface; thin stratum granulosum with parakeratosis. Described as a coral-colored plaque coated in silver scales that is typically found on the scalp, knees, and elbows; positive Auspitz sign, which is characterized by small regions of blood when scales are removed; nail discolouration or pitting with nail plate and nail bed separation. linked to a higher risk of cardiovascular disease, myopathy, enteropathy, and psoriatic arthritis. For severe cases, treatment options include methotrexate or other immunomodulators, topical corticosteroids, and exposure to UVB light.
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