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Pathology - Sarcoidosis
Pathophysiology
The majority of cases of this multisystem granulomatous noninfectious disease are observed in female African Americans. Nearly all organ systems are susceptible to the illness, however joint, liver, eyes, and lungs are the most frequently affected. It is believed that a heightened cell-mediated immune response to different antigens is the root cause of the illness (s). Targeting CD4+ T-cells in the lungs results in noncaseating granulomas and alveolitis, both of which can develop into fibrosis. Patients frequently arrive with fatigue and dyspnea symptoms. Another typical set of presenting symptoms include systemic symptoms like weariness, sweats at night, and gradual weight loss. In addition, the patient may suffers iritis from sarcoidosis. Systemic steroid medication may cause remission during treatment, although pulmonary fibrosis progresses in many individuals over time.
Pathophysiology
The majority of cases of this multisystem granulomatous noninfectious disease are observed in female African Americans. Nearly all organ systems are susceptible to the illness, however joint, liver, eyes, and lungs are the most frequently affected. It is believed that a heightened cell-mediated immune response to different antigens is the root cause of the illness (s). Targeting CD4+ T-cells in the lungs results in noncaseating granulomas and alveolitis, both of which can develop into fibrosis. Patients frequently arrive with fatigue and dyspnea symptoms. Another typical set of presenting symptoms include systemic symptoms like weariness, sweats at night, and gradual weight loss. In addition, the patient may suffers iritis from sarcoidosis. Systemic steroid medication may cause remission during treatment, although pulmonary fibrosis progresses in many individuals over time.
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