- Published on
Pathology - Schizophrenia
Pathogenesis
Delusions, hallucinations, disorganized behavior/catatonia, disorganized speech, and negative symptoms are the DSM-IV criteria for schizophrenia. These criteria require more than six months of disturbed functioning with at least one month of at least two of the following symptoms (unless delusions are bizarre or voices provide running commentary, in which case only one criterion is required). The cause of these symptoms is a reduction in dopaminergic activity. Positive symptoms (delusions and hallucinations) originate from the mesolimbic system, whereas negative symptoms (anhedonia, flat affect, avolition) are sourced from the frontal cortical region. Dopamine antagonists are the standard of care. However, atypical antipsychotics are typically the first-line medication because to the high incidence of tardive dyskinesia and extrapyramidal symptoms linked to D2 dopamine receptor blockage in conventional antipsychotics.
Pathogenesis
Delusions, hallucinations, disorganized behavior/catatonia, disorganized speech, and negative symptoms are the DSM-IV criteria for schizophrenia. These criteria require more than six months of disturbed functioning with at least one month of at least two of the following symptoms (unless delusions are bizarre or voices provide running commentary, in which case only one criterion is required). The cause of these symptoms is a reduction in dopaminergic activity. Positive symptoms (delusions and hallucinations) originate from the mesolimbic system, whereas negative symptoms (anhedonia, flat affect, avolition) are sourced from the frontal cortical region. Dopamine antagonists are the standard of care. However, atypical antipsychotics are typically the first-line medication because to the high incidence of tardive dyskinesia and extrapyramidal symptoms linked to D2 dopamine receptor blockage in conventional antipsychotics.
0 Comments
