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Pathology - Scurvy
caused by a lack of vitamin C, typically from insufficient consumption.
Pathophysiology: Insufficient vitamin C leads to decreased collagen synthesis and a reduction in osteoblasts' ability to create osteoid matrix.
Bone: Reduced osteoid matrix; expansion of cartilaginous material without osteoid replacement of the epiphyseal cartilage.
Clinical Signs and Symptoms
bleeding into joint spaces, purpura and petechiae, subperiosteal hemorrhage, gingival edema, anemia, exhaustion, and poor wound healing.
Results from the lab: reduced Hct and decreased plasma ascorbic acid.
Supplemental vitamin C for treatment.
caused by a lack of vitamin C, typically from insufficient consumption.
Pathophysiology: Insufficient vitamin C leads to decreased collagen synthesis and a reduction in osteoblasts' ability to create osteoid matrix.
Bone: Reduced osteoid matrix; expansion of cartilaginous material without osteoid replacement of the epiphyseal cartilage.
Clinical Signs and Symptoms
bleeding into joint spaces, purpura and petechiae, subperiosteal hemorrhage, gingival edema, anemia, exhaustion, and poor wound healing.
Results from the lab: reduced Hct and decreased plasma ascorbic acid.
Supplemental vitamin C for treatment.
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