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Pathology - The Toxicology of Digitalis
Pathophysiology
This disorder arises when serum levels of digitalis, which is administered as a positive inotropic drug to certain patients suffering from congestive heart failure, above a very specific therapeutic range. Fatigue, nausea, vomiting, abdominal discomfort, and agitation or disorientation are typical symptoms. ECG abnormalities are common and can take many different forms. There may be ventricular tachycardia, bradycardia, rapid idioventricular rhythm, or paroxysmal atrial tachycardia with heart block.
Low serum potassium levels aggravate the illness and the arrhythmias that follow. Digoxin immune Fab therapy is recommended.
However, lidocaine, phenytoin, and magnesium can be utilized in the event that immunological Fab is not accessible.
Pathophysiology
This disorder arises when serum levels of digitalis, which is administered as a positive inotropic drug to certain patients suffering from congestive heart failure, above a very specific therapeutic range. Fatigue, nausea, vomiting, abdominal discomfort, and agitation or disorientation are typical symptoms. ECG abnormalities are common and can take many different forms. There may be ventricular tachycardia, bradycardia, rapid idioventricular rhythm, or paroxysmal atrial tachycardia with heart block.
Low serum potassium levels aggravate the illness and the arrhythmias that follow. Digoxin immune Fab therapy is recommended.
However, lidocaine, phenytoin, and magnesium can be utilized in the event that immunological Fab is not accessible.
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