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Pathology - Vaginal neoplasms
Vaginal carcinoma • Rare relative to cervical and vulvar carcinomas. • Predominantly squamous cell carcinomas originating from a precursor dysplastic lesion termed vaginal intraepithelial neoplasia (VAIN).
• Risk factors encompass HPV infection, tobacco use, and immunosuppression. • Prognosis is typically unfavorable, with a 5-year survival rate of approximately 60%. Fibroepithelial stromal polyp • Benign lesion of the distal female genital system, primarily affecting the vagina, but may also occur in the vulva. • Hormonal-responsive lesions manifesting in women of reproductive age as tiny polypoid masses.
• Histologically, they consist of a central fibrovascular core enveloped by hyperplastic squamous epithelium. Stellate and multinucleate stromal cells are generally observed within the core next to the epithelial surface.
Genital rhabdomyoma • A benign tumor exhibiting skeletal muscle differentiation, predominantly found in the vagina. • Typically manifests in middle-aged women with symptoms associated with a mass lesion. • Histologically characterized by a disorganized proliferation of spindle cells featuring abundant, brightly eosinophilic cytoplasm with cross-striations.
Embryonal rhabdomyosarcoma is a malignant tumor exhibiting skeletal muscle differentiation, which may develop in the vagina of children. The majority of cases occur in children under 5 years of age, presenting with vaginal hemorrhage. A tumor may be observed protruding through the vaginal entrance. • Macroscopically, the tumor consists of edematous polypoid nodules protruding from the vaginal wall. • Histologically, the tumor comprises tiny round and spindle-shaped cells aggregated beneath the squamous epithelium of the vaginal wall. Certain tumor cells have prominently eosinophilic cytoplasm, with potential visibility of cytoplasmic cross-striations. The prognosis post-treatment is typically outstanding, with 10-year survival rates above 90%.
Vaginal carcinoma • Rare relative to cervical and vulvar carcinomas. • Predominantly squamous cell carcinomas originating from a precursor dysplastic lesion termed vaginal intraepithelial neoplasia (VAIN).
• Risk factors encompass HPV infection, tobacco use, and immunosuppression. • Prognosis is typically unfavorable, with a 5-year survival rate of approximately 60%. Fibroepithelial stromal polyp • Benign lesion of the distal female genital system, primarily affecting the vagina, but may also occur in the vulva. • Hormonal-responsive lesions manifesting in women of reproductive age as tiny polypoid masses.
• Histologically, they consist of a central fibrovascular core enveloped by hyperplastic squamous epithelium. Stellate and multinucleate stromal cells are generally observed within the core next to the epithelial surface.
Genital rhabdomyoma • A benign tumor exhibiting skeletal muscle differentiation, predominantly found in the vagina. • Typically manifests in middle-aged women with symptoms associated with a mass lesion. • Histologically characterized by a disorganized proliferation of spindle cells featuring abundant, brightly eosinophilic cytoplasm with cross-striations.
Embryonal rhabdomyosarcoma is a malignant tumor exhibiting skeletal muscle differentiation, which may develop in the vagina of children. The majority of cases occur in children under 5 years of age, presenting with vaginal hemorrhage. A tumor may be observed protruding through the vaginal entrance. • Macroscopically, the tumor consists of edematous polypoid nodules protruding from the vaginal wall. • Histologically, the tumor comprises tiny round and spindle-shaped cells aggregated beneath the squamous epithelium of the vaginal wall. Certain tumor cells have prominently eosinophilic cytoplasm, with potential visibility of cytoplasmic cross-striations. The prognosis post-treatment is typically outstanding, with 10-year survival rates above 90%.
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