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Pharmacology - Alteplase
Action in the Alteplase
It does this by activating plasminogen through an enzyme, which then produces plasmin, which then digests fibrin and fibrinogen, hence lysis the clot.
IV injection or intravenous infusion; the half-life is rather short.
Use in Clinical Settings
Acute ischemic stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism are all examples of cardiovascular emergencies.
Adverse Effects
Most importantly, bleeding, reperfusion dysrhythmias, nausea and vomiting, and hypersensitivity reactions are all potential complications.
Within the first twelve hours after the commencement of the condition, it must be administered, and ideally within the first hour.
Reteplase, a drug with a similar effect (extended half-life).
Action in the Alteplase
It does this by activating plasminogen through an enzyme, which then produces plasmin, which then digests fibrin and fibrinogen, hence lysis the clot.
IV injection or intravenous infusion; the half-life is rather short.
Use in Clinical Settings
Acute ischemic stroke, myocardial infarction, deep vein thrombosis, and pulmonary embolism are all examples of cardiovascular emergencies.
Adverse Effects
Most importantly, bleeding, reperfusion dysrhythmias, nausea and vomiting, and hypersensitivity reactions are all potential complications.
Within the first twelve hours after the commencement of the condition, it must be administered, and ideally within the first hour.
Reteplase, a drug with a similar effect (extended half-life).
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