​Pharmacology - Aripiprazole

​Pharmacology - Aripiprazole 
Antipsychotic medication. Useful in treating both positive and negative symptoms.

Method of Operation 
In the mesolimbic and mesocortical pathways, the modification of dopaminergic transmission. However, aripiprazole also exhibits partial agonist action, which may be the reason for its low frequency of EPS. Aripiprazole has a significant binding affinity for dopamine D2 receptors. It is likely that 5HT2A antagonistism is significant. Oral admin. Extended half-life (75 hours).

Use in Clinical Settings 
Both schizophrenia and other psychotic conditions are included. During the manic phase of bipolar illness...

Adverse Effects
There are less adverse effects compared with many other antipsychotics, such as mild EPS (some akathisia), less weight gain, significantly less antimuscarinic, and significantly less prolactin production. Some hypotension, nausea, and vomiting are also present.