​Pharmacology - Bupropion

​Pharmacology - Bupropion
The 'atypical' antidepressant action of bupropion. Improves one's  mood

Method of Operation 
A neuronal dopamine reuptake inhibitor that is rather selective, having a lesser effect on noradrenaline and very little effect on the uptake of 5-HT. Also acts as an antagonist at nicotinic receptors found in neurons. Oral admin. A significant amount of hepatic metabolism by Cyt P450 results in the production of active metabolites, which are a component of the antidepressant activity. 20 hours is the half life.

Use in Clinical Settings
When treating serious depression, either on its own or in conjunction with SSRIs. Additionally used to assist individuals in quitting smoking tobacco. The development of clinical effects can take several weeks.

Adverse Effects
Agitation, tremor, dry mouth, nausea, sleeplessness, and skin rashes are some of the side symptoms that one may experience. The weight gain and sexual dysfunction that are prevalent side effects of other antidepressants are not caused by this medication. When used in higher quantities, seizures may be triggered.