Pharmacology - Cimetidine

Pharmacology -  Cimetidine 
The production of stomach acid is inhibited. The action of histamine that is released from mast cell-like cells in the gastric mucosa is inhibited by this substance. Acid secretion that is induced by gastrin or vagal stimulation is somewhat inhibited by this substance.

Method of Operation 
On parietal cells, selective, reversible, and competitive blockade of histamine H2 receptors is being demonstrated.

Ingestion of the medication. (the half life is two hours, while ranitidine is three hours).

Use in Clinical Settings 
Both duodenal and peptic ulcers are present. A illness known as gastroesophageal reflux. NSAID-induced ulcers as a result of discontinuing the use of the NSAID.

Adverse Reaction 
Rarely seen. Symptoms include headaches and gastrointestinal distress.
gynecomastia in males and galactorrhea in females are effects that are associated with cimetidine but not with other H2 blockers.
Senior citizens who are confused and disoriented. Actions that are antiandrogenic

One of the most powerful cytochrome P450 inhibitors is cimetidine, which is not the case with the other H2 antagonists. As a result of the elevated plasma concentration of other medications, such as propranolol, benzodiazepines, phenytoin, and warfarin, there are several interactions happening. Ranitidine and cimetidine are two medications that decrease the renal tubular secretion of other medications.