Pharmacology - Diazepam

Pharmacology - Diazepam 
​Anxiolytic, hypnotic, amnestic, anticonvulsant, and a reduction in muscular tone are some of the actions that diazepam can have.

Method of Operation 
Binds to the benzodiazepine binding site on the GABAA receptor, which causes the channel opening caused by GABA to be increased.
A decrease in neuronal excitability is brought about by the increased Cl– conductance.

Orally administered. Because it is an active metabolite with a lengthy half life, diazepam has a long duration of action. Both nitrazepam and temazepam have a median duration of action. Oxazepam has a relatively brief duration of action.

Use in Clinical Settings 
Anxiety and sleeplessness are symptoms. In the field of hypnotics, temazepam and nitrazepam are utilized. Aside from that, premedication and status epilepticus are two further uses for diazepam.

Adverse Reactions
Both drowsiness and bewilderment are present. There is a possibility of developing tolerance and dependency, along with withdrawal symptoms, as well as severe respiratory depression when combined with other central nervous system depressants, such as alcohol.