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Pharmacology - Ezetimibe
The action of Ezetimibe
In particular, it prevents cholesterol from being absorbed from the intestines during digestion. A decrease in the concentration of LDL in plasma is the primary effect.
Mode of Operation
The quantity of biliary and dietary C that is transported to the liver via chylomicrons is decreased as a result of the blocking of a sterol carrier protein in the brush border of enterocytes with this substance. Because of this, there is an increase in the C store of the liver, an increase in the absorption of LDL by the liver, and a clearance of LDL-C from the plasma.
When taken orally, it is activated in the liver, and it reaches its maximum concentration in two hours. After that, it goes through the process of enterohepatic cycling, and over time, it is eliminated through the feces. The half-life of plasma is 22 hours.
On the other hand, colestyramine has the opposite effect, lowering plasma concentrations while fibrates raise them.
Use in Clinical Settings
In most cases, hypercholesterolemia is treated in conjunction with a statin.
Adverse Effects
Just a few of them. Headaches, rashes, and myalgia are some of the symptoms that could take place.
The action of Ezetimibe
In particular, it prevents cholesterol from being absorbed from the intestines during digestion. A decrease in the concentration of LDL in plasma is the primary effect.
Mode of Operation
The quantity of biliary and dietary C that is transported to the liver via chylomicrons is decreased as a result of the blocking of a sterol carrier protein in the brush border of enterocytes with this substance. Because of this, there is an increase in the C store of the liver, an increase in the absorption of LDL by the liver, and a clearance of LDL-C from the plasma.
When taken orally, it is activated in the liver, and it reaches its maximum concentration in two hours. After that, it goes through the process of enterohepatic cycling, and over time, it is eliminated through the feces. The half-life of plasma is 22 hours.
On the other hand, colestyramine has the opposite effect, lowering plasma concentrations while fibrates raise them.
Use in Clinical Settings
In most cases, hypercholesterolemia is treated in conjunction with a statin.
Adverse Effects
Just a few of them. Headaches, rashes, and myalgia are some of the symptoms that could take place.
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