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Pharmacology - Flucytosine
is changed into the antimetabolite 5-fluorouracil in fungal cells (but not in human cells), which prevents DNA synthesis by blocking thymidylate synthetase.administered orally, but also by intravenous infusion. Plasma half-life ~4h.
Application in Clinical Practice
Systemic candidiasis and cryptococcal meningitis are examples of systemic fungal and yeast infections.
Negative Results
GIT disturbances; rashes. Headaches, disorientation, blood dyscrasias, and cardiotoxicity are less frequent. As resistance may develop, amphotericin is typically administered in addition.
is changed into the antimetabolite 5-fluorouracil in fungal cells (but not in human cells), which prevents DNA synthesis by blocking thymidylate synthetase.administered orally, but also by intravenous infusion. Plasma half-life ~4h.
Application in Clinical Practice
Systemic candidiasis and cryptococcal meningitis are examples of systemic fungal and yeast infections.
Negative Results
GIT disturbances; rashes. Headaches, disorientation, blood dyscrasias, and cardiotoxicity are less frequent. As resistance may develop, amphotericin is typically administered in addition.
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