​Pharmacology - Fluoxetine

​Pharmacology - Fluoxetine 
The antidepressant medication fluoxetine

Method of Operation 
The reuptake of 5-HT into serotonergic neurons is inhibited, which results in the enhancement of the effect of the transmitter. Due to the fact that longer-term modifications (such as the downregulation of receptors) are required for this, the antidepressant activity begins to manifest itself after a few weeks have passed. (Comparatively less pronounced antihistaminergic and antimuscarinic effects than those of the TCAs.)
Ingestion of the medication. Brain attention improves over the course of a few days. Following the completion of conjugation processes, hepatic P450 metabolism occurs.The half life is between one and three days. This active metabolite has a longer duration. (The half-lives of other selective serotonin reuptake inhibitors are as follows: 18–24 hours for paroxetine, 18–24 hours for fluvoxamine, 24–36 hours for escitalopram, and 24–36 hours for sertraline.) Consistently bonded together. The enantiomer of citalopram that is functional is called escitalopram. Among the selective selective serotonin reuptake inhibitors (SSRIs), sertraline and escitalopram are the most advantageous.

Use in Clinical Settings 
Most commonly prescribed. There is depression. An obsessive-compulsive disorder (OCD). Panic disorder. Bulimia nervosa is a disorder.

Adverse Effects 
The symptoms of nausea, diarrhea, and headaches might be brought on by anxiety and insomnia. Sexual dysfunction is a problem. There is a higher likelihood of suicide among younger patients. Not recommended for use with MAOIs due to the potential for serotonin syndrome.
In older patients, hyponatremia can occur. Overdose toxicity is significantly lower than that of TCAs.