​Pharmacology - Glucagon

​Pharmacology - Glucagon 
An Action of Glucagon 
It raises the concentration of glucose in the blood. boosts both the rate and the force of the heart's contractions.

Method of Operation 
Adenylate cyclase is activated by glucagon, which does this via acting on G-protein coupled receptors that are related to Gs. Beta-adrenoceptors are activated by its activities, which are hence similar to those of adrenaline. Through the stimulation of hepatic gluconeogenesis and glycogenolysis, as well as the inhibition of glycogen synthesis, it causes an increase in blood glucose levels.

It is necessary to provide glucagon through injection because it is a peptide hormone. Plasma has a half-life of five minutes.

Use in Clinical Settings 
In situations where oral or intravenous glucose administration is not feasible, emergency treatment of hypoglycemic emergencies (induced by insulin overdose) requires immediate attention. In addition, it is utilized in the treatment of heart failure that is brought about by beta-adrenoceptor antagonists.

Adverse Effects
Rarely seen. In patients who are using beta-blockers or who have phaeochromocytoma, cardiac stimulation is administered.