​Pharmacology - Griseofulvin

​Pharmacology - Griseofulvin
Fungal cell mitosis is interfered with, resulting in fungistatic action.

Method of Operation
Interacts with polymerized microtubules limiting spindle formation.
When taken orally, it is absorbed by skin cells that are growing and attaches to keratin. Half-life ~24h.

Application in Clinical Practice
 Fungal infections of skin, hair and scalp; trichophyton infections in children.

Negative Outcomes
 Headache and GIT disruptions are uncommon.