​Pharmacology - Isoniazid

​Pharmacology - Isoniazid 
For dormant mycobacteria, isoniazid acts as a bacteriostat; for actively growing mycobacteria, it kills them all.

Mode of Action 
The production of mycolic acids, which are essential building blocks of mycobacterial cell walls, is interrupted.

Administered orally and absorbed fully. Enters cerebrospinal fluid and TB lesions. Transported into cells and absorbed by tuberculosis bacilli. This drug is acetylated in the liver; some people metabolize it slowly because of their genes, while others metabolize it quickly and have a poorer response to the medication.

Clinical Use 
Tuberculosis 

Risk of Side Effects
Potential side effects include gastrointestinal (GI) problems, allergic responses, peripheral neuritis (when administered at large doses, pyridoxine prophylaxis is necessary), and other similar conditions.